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Published 09:57 1 Sept 2016 BST
Updated 13:51 1 Sept 2016 BST
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The match has the added spice this year of being the first time Mourinho will face his old foe Pep Guardiola since the former La Liga rivals started at their new clubs in the Premier League.
Mkhitaryan has not yet started a Premier League match for United, but has come on in every game so far, and impressed when he came on against Hull City last weekend. On MUTV, Mourinho said:
"We keep eight outfield players and Sam Johnstone as the goalkeeper. We are going to lose the others and we don't know the way they train, the way they recover, the life they are going to have with their national teams."Mkhitaryan was in line for a start. Now he will be lucky to even make the squad.
The new GAA Hour football podcast is here. Listen to Colm Parkinson, Senan Connell, and Barry Cahill dissect a classic between Dublin and Kerry. Subscribe here on iTunes.

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