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Published 14:36 8 Apr 2021 BST
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Eimear Considine returns to the full-back jersey as one of the three changes in personnel from the victory over Italy last time out, with Lauren Delany switching to the right wing and Beibhinn Parsons lining out on the left.
There is an unchanged front row named by Griggs as Lindsay Peat, Cliodhna Moloney and Linda Djougang once again pack down together, with the fit-again Aoife McDermott returning to the second row alongside Nichola Fryday.
Griffin leads the side from number eight, with Dorothy Wall set for her fifth cap at blindside flanker and Claire Molloy named at openside.
"We have had a great deal of time to prepare together," said Griggs, "and this group of players have earned the responsibility to bring the high standards we have set ourselves throughout training into this first game. "Wales at home will bring a strong challenge and we need to make sure we start the game well and build a platform that allows us to play our game and start this competition off with a win."
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