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Published 15:05 31 Oct 2016 GMT
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Jackson's absence means that Leinster young gun Joey Carbery will be Sexton's back-up fly-half on the bench against the World Champions.
Ireland were devastatingly close to recording a first ever victory over the New Zealanders the last time they met, in 2013, when Johnny Sexton's late penalty miss proved crucial - as the Kiwis miraculously worked the ball up the field for Ryan Crotty to get over for a late equalising try in the corner. At the second attempt, Aaron Cruden added the game-winning conversion.
Ireland will hope to avenge that 24-22 defeat, but face an uphill battle against an All Blacks side that are unbeaten since losing the 2015 Bledisloe Cup to Australia.
27-man squad travelling to Chicago
Finlay Bealham (Buccaneers/Connacht)
Rory Best (Banbridge/Ulster) captain
Joey Carbery (Clontarf/Leinster)*
Sean Cronin (St Marys/Leinster)
Ultan Dillane (Corinthians/Connacht)
Tadgh Furlong (Clontarf/Leinster)
Craig Gilroy (Bangor/Ulster)
Cian Healy (Clontarf/Leinster)
Jamie Heaslip (Dublin University/Leinster) vice captain
Robbie Henshaw (Buccaneers/Leinster)
Billy Holland (Cork Constitution/Munster)*
Rob Kearney (UCD/Leinster)
Kieran Marmion (Buccaneers/Connacht)
Jack McGrath (St Mary's College/Leinster)
Luke McGrath (UCD/Leinster)*
Jordi Murphy (Lansdowne/Leinster)
Conor Murray (Garryowen/Munster)
Jared Payne (Ulster)
Garry Ringrose (UCD/Leinster)*
Donnacha Ryan (Shannon/Munster)
John Ryan (Cork Constitution/Munster)*
Jonathan Sexton (St Marys/Leinster)
CJ Stander (Shannon/Munster)
Devin Toner (Lansdowne/Leinster)
Andrew Trimble (Ballymena/Ulster)
Josh van der Flier (UCD/Leinster)
Simon Zebo (Cork Constitution/Munster)
Colm Parkinson is joined by Paul Rouse for a heated debate about Sky Sports' five-year GAA deal and an exclusive chat with AFL star Zach Tuohy on the new GAA Hour. Subscribe here on iTunes
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