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Published 12:37 7 Apr 2017 BST
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Replays of the incident prompted supporters to fear the worst, especially considering the struggles that the side encountered when the Senegal international was on international duty throughout the Africa Cup of Nations.
But there remained that glimmer of hope that he would not require surgery and that Mane would be all good to go after a week or two of rest.
Well that hope has been dashed by Jurgen Klopp who, at his pre-match press conference on Friday, confirmed fans' worst fears.
https://twitter.com/IanDoyleSport/status/850302003486089216?ref_src=twsrc%5Etfw&ref_url=http%3A%2F%2Fwww.liverpoolecho.co.uk%2Fsport%2Ffootball%2Ffootball-news%2Fjurgen-klopps-press-conference-live-12859013
https://twitter.com/IanDoyleSport/status/850301888310456320?ref_src=twsrc%5Etfw&ref_url=http%3A%2F%2Fwww.liverpoolecho.co.uk%2Fsport%2Ffootball%2Ffootball-news%2Fjurgen-klopps-press-conference-live-12859013
Added to that, Klopp confirmed that neither Jordan Henderson nor Adam Lallana will have recovered from their own injury problems for this weekend's trip to Stoke City, while Philippe Coutinho is a doubt through illness.
Mane's absence is a significant blow for Klopp due to the fact that the former Southampton winger has 13 goals and five assists to his name this season.
And fans learning of the news felt that their fate was sealed with the unwelcome update.
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