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Published 20:25 29 Jul 2016 BST
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Karius hurt his hand during Liverpool's defeat to Chelsea on Wednesday after he collided with defender Dejan Lovren as he attempted to punch clear a cross into the box.
Visibly uncomfortable, the 23-year-old opted to play on but was sent for a scan on Thursday where a fracture was discovered.
He will leave Liverpool's California training base on Friday to return for treatment at Melwood.
Mignolet is therefore almost certain to start the Reds' Premier League opener away to Arsenal while Klopp has luckily brought in further cover in the form of veteran stopper Alex Manninger.
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