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Published 16:33 28 Mar 2016 BST
Updated 20:52 28 Mar 2016 BST
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Injuries to Kevin Doyle, Daryl Murphy, Jon Walters and Robbie Keane have even led to the likes of Leon Best throwing his hat in the ring for a shot at a call-up.
But O'Neill maintains that he will not be bringing any new faces into the fold for the Aviva clash and hinted at the prospect of playing McClean in a more advanced role.
“I’m not going to bring anyone in at this late notice,” O’Neill said in Monday's press conference.
“We can adjust things. James McClean has played up front before, I’ve seen him play for Wigan there where he has done exceptionally well. So I think we can change things around.
"It’s been a bit of a disruption. For a start, I wanted Kevin Doyle to play at least for an hour if not the whole game. It was an opportunity for him and he started the game quite well but was unfortunate to get injured.
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Quiz: Put these PFA Players’ Player of the Year winners in order